Next, to deeply explore the mechanism of the p53 signaling pathway involved in PRMT7-inducing cancer-related phenotypes, we performed H4R3me2s ChIP in the QGY-7703 cell lines, and then detected the enrichment of H4R3me2s on the CAGCTG motif-resided regions in the promoter of genes by qPCR. This evidence concerns the gene PRMT7 and cancer.