We have demonstrated that the HCC risk allele G of rs73613962 inside the intron of target gene PRMT7 enhanced the binding of HNF4A, and HNF4A in turn promoted the expression of PRMT7. We therefore asked whether the elevated expression of PRMT7 would contribute to cancer-associated cellular phenotypes and thus lead to high HCC risk. This evidence concerns the gene HNF4A and hepatocellular carcinoma.