Through function enrichment analysis of the differentially expressed genes by the Database for Annotation, Visualization and Integrated Discovery (DAVID), we found that the p53 signaling pathway which plays an important role in cancer development ranked the top 1, implying that these genes enriched in this pathway may be involved in PRMT7-mediated HCC development (Fig. 6a, b). Here, TP53 is linked to hepatocellular carcinoma.