We find that the risk allele G of rs73613962 corresponds to higher enhancer activity, which promotes the expression of its host gene PRMT7. Mechanistically, transcription factor HNF4A prefers to bind to the risk allele G-containing enhancer sequence and promotes PRMT7 expression, which ultimately leads to cancer-related phenotypes via the modification of H4R3me2s to regulate p53 signaling pathway (Fig. 7). Here, HNF4A is linked to cancer.