To examine whether the rs73613962-containing region plays a causal role in PRMT7 expression, in cis mutation, repression, and activation by CRISPR-Cas9, dCAS9-KRAB (CRISPR-interference, CRISPRi), and dCAS9-VP48 (CRISPR-activation, CRISPRa) assays, respectively, were performed in HCC cell lines, with small guide RNAs (sgRNAs) targeting the region surrounding rs73613962 (Fig. 3c, d, g). The gene discussed is PRMT7; the disease is hepatocellular carcinoma.