At replication stage 1, the six screened candidate SNPs were assessed for association with HCC risk, and only rs73613962 (T > G), located in the intronic region of PRMT7 at 16q22.1 (Fig. 1b), was validated (P < 0.05, and with the same direction of association as in the discovery stage, the minor allele G is the risk allele, whereas the major allele T is the non-risk allele; Fig. 1c, Supplementary Table 2). The gene discussed is PRMT7; the disease is hepatocellular carcinoma.