Due to the preferential binding of HOXA2 to the risk allele G of rs11672691, the transcriptional levels of two biologically plausible candidate genes, the long noncoding RNA (lncRNA) PCAT19 and protein-coding gene CEACAM21, are elevated, and consequently promote prostate cancer cell growth and tumor progression14. This evidence concerns the gene PCAT19 and Familial prostate cancer.