HSP90AA1 and plasma cell myeloma: Our scRNA-seq data in (representative t-SNE clusters shown in Fig. 2) demonstrated that the majority of the single-cell clusters in drug-sensitive and drug-resistant myeloma have high expression of 17-AAG target genes HSP90AA1, HSP90AB1, and the FK866 target gene NAMPT indicating that 17-AAG and FK866 combination may be effective against these subpopulation clusters.