Proteasome inhibitors (PIs) are standard-of-care chemotherapeutic agents for myeloma that impede tumor metastasis and angiogenesis by accelerating unfolded protein response (UPR) or the ubiquitin-dependent proteolysis of important regulatory proteins involved in key physiological and pathophysiological cellular processes in cancer cells and by interfering with the NF-κB-enabled regulation of cell adhesion-mediated drug resistance [2–6]. Here, NFKB1 is linked to plasma cell myeloma.