Aronchik and his colleagues [25] reported that indole-3-carbinol (I3C), a compound derived from cruciferous vegetables, could inhibit the functions of NEDD4-1 and WWP1 through targeting the HECT domain, thus abrogating the proliferation and metastasis of melanoma or prostatic carcinoma. The gene discussed is WWP1; the disease is prostate carcinoma.