We found significantly higher levels of autoantibodies mostly directed against 11 receptors (AGTR1, AGTR2, ADRB1, BDKRB1, MAS1, CXCR3, CHRM3, CHRM5, NRP1, F2R, STAB1) in the moderate or severe COVID-19 groups than in the healthy control and mild COVID-19 group (Fig. 2a and b). This evidence concerns the gene CHRM5 and COVID-19.