CHRM5 and COVID-19: Follow-up analysis indicated that CXCR3-aab, AGTR1-aab, MAS1-aab, CHRM5-aab, and BDKRB1-aab were the five most significant predictors of COVID-19 disease-severity classification based on the number of nodes and the Gini decrease criteria for measuring variable importance (Fig. 4e and f).