Thus, disturbances in mitochondrial ICS biosynthesis could contribute to failures in the supply of energy (which might result in cell death) or to cancer, since genomic instability is considered as a hallmark of cancer and a driver of neoplastic transformation processes.5 Mutations in SLC25A39 can alter mitochondrial GSH levels (Fig. 1b) and thereby interfere with ICS biosynthesis which in turn can have an impact on the development of cancer. The gene discussed is SLC25A39; the disease is cancer.