This corresponded to the heterogeneity seen in the ROIs from the metastasis wedge resection, where the ROIs within the tumor bed were more highly correlated with the bulk RNAseq (median 0.69, 0.67–0.71 with DSP RNA; median 0.51, 0.47–0.55 with DSP protein) compared with the invasive margin of the tumor (median 0.43, 0.38–0.62 with DSP RNA; median 0.36, 0.24–0.48 with DSP protein). Here, DSP is linked to neoplasm.