IDH2 and astrocytoma (excluding glioblastoma): Methylation profiling was performed with UMAP analysis on 245 IDH-mutant astrocytomas, and identified 57 cases (23.3%) with a similar pattern of methylation probe levels to cluster 1 of the reference cohort (CIN) and 188 cases with similar methylome characteristics to cluster 2 of the reference cohort (CS) (Fig. 2a–c).