While there are few studies that investigate the effect of CIN and overall CNV in diffuse gliomas, we and others have used large publicly-available and institutional cohorts of IDH-mutant astrocytoma and IDH-wildtype glioblastoma to demonstrate that CIN can be readily identified through whole genome copy number profiling and whole exome sequencing in certain subsets. This evidence concerns the gene IDH1 and glioblastoma.