Because of the above, our objective is to evaluate the following alterations involved with coagulation genes, which could be associated with LCPD etiology: MTHFR C677T rs1801133, CBS T833C rs115742905, and PT G20210A rs1799963; the following collagen-related polymorphisms: COL1A1 G1997T rs1107946, COL1A1 C1663T rs2412298, COL2A1 G2306A rs121912891, and COL2A1 G3665A rs387106558; and their relationship with Mexican patients suffering from LCPD. Here, COL2A1 is linked to Legg-Calve-Perthes disease.