To enhance the prediction efficacy of genetic predictors, we selected two additional variations, rs2231142.GG of ABCG2 and rs11231463.GG of SLC22A9/OAT7, based on their contributions to gout in the development cohort (Supplementary Table S1) and their effects on renal urate handling as reported [7–9, 11]. The gene discussed is ABCG2; the disease is gout.