For instance, after the cathepsin S was inhibited, TNBC had a reduced ability to grow and metastasize [45], TGF-β reversed PI3K/AKT/mTOR pathway-induced changed in EMT and tight junction proteins, which in turn inhibit aggressive growth and distant metastasis of glioblastoma [46], the secretion of progesterone and estradiol in rabbit ovarian granulosa cells was regulated and cell proliferation was inhibited. The gene discussed is TGFB1; the disease is glioblastoma.