The result showed that lnc-BRF2-7 and TNFRSF10A-AS1 were highly expressed in COAD compared to normal tissues (both p < 0.05), while the expression of lnc-PRPF18-1, HAND2-AS1, and lnc-MOCS1-1 was decreased in COAD compared to normal tissues (all p < 0.05). The gene discussed is HAND2; the disease is colon adenocarcinoma.