EGFR and non-small cell lung carcinoma: Neurofibromin 1 (NF1) is a GTPase-activating protein that inhibits the Ras signaling pathway, which, in turn, inhibits the MAP-ERK kinase MiR-641 up-regulation in EGFR-TKI-resistant NSCLC cells promoted Erlotinib resistance in NSCLC cells by directly targeting NF1 via activation of ERK signaling.