It has a critical role in lung cancer via regulation apoptosis and cell cycle-related genes such as Tumor protein P53 (p53), B-Cell Lymphoma 2 (BCL-2), Cyclin D1 (CCND1), and Cyclin Dependent Kinase Inhibitor 1A (CDKN1A) [190]. This evidence concerns the gene CDKN1A and lung carcinoma.