TNF Superfamily Member 12 (TNFSF12) belongs to the Tumor Necrosis Factor (TNF) protein family expressed in a range of organs, immune cell types, and tumor cells, which activates caspase 8 and caspase 9 and cause extrinsic and intrinsic apoptosis cascades [204]. The gene discussed is TNFSF12; the disease is neoplasm.