CD274 and non-small cell lung carcinoma: Finally, in a previous US-based analysis of real-world treatment patterns and outcomes before and after FDA approval of anti–PD-1/PD-L1 therapies for NSCLC, approximately half (48.8%) of patients receiving a second-line therapy after FDA approval received an anti–PD-1/PD-L1 therapy [26]; this proportion is noticeably similar to that observed in the current study for second-line I-O therapy (46.9%).