In addition, berberine decreased the production of TNF‐α, IFN‐γ, IL‐2, IL‐1β, increased the level of IL‐10 and alleviated hepatitis by blocking the transcriptional activity of signal transducer and activator of transcription 1 (STAT1), which was largely dependent on activating AMPK.40 This evidence concerns the gene STAT1 and hepatitis A virus infection.