MYC and cancer: As a consequence, MYC overexpression is often observed in cancer cells.[44] The interaction of MYC with WD repeat‐containing protein 5 (WDR5) is a key interaction in carcinogenesis and its interaction site has been recognized as a target for small‐molecule inhibitors.[45] By high throughput screening (HTS), Macdonald et al.[17] identified compound 4 as a hit showing inhibitory effects (Figure 3).