The piperazine ring served as an attachment point for the VHL‐ligase ligand through a 6‐carbon amide linker (as shown in Figure 6A).[36] In MOLT‐4 cells (Bcl‐xL‐dependent T‐cell acute lymphoblastic leukemia, “T‐ALL”), the DT2216 showed a rapid and long‐lasting (Dmax=90.8 %) Bcl‐xL protein degradation (DC50=63 nM). This evidence concerns the gene BCL2L1 and acute lymphoblastic leukemia.