However, we have recently shown that RSV infection results in proteolytic cleavage of β2AR, non-canonical activation of adenylyl cyclase impairing cAMP synthesis, and increased muscle contractility due to higher cytosolic calcium concentration, with the net effect of favoring airway obstruction and reducing the bronchodilator effect of β2AR agonists [16]. This evidence concerns the gene ADRB2 and Airway obstruction.