A total of nine proteins were significantly increased in subjects with a combined diagnosis of airflow obstruction and CAD compared with those without a combined diagnosis: VSIG2, Kidney Injury Molecule (KIM1), Fibroblast growth factor 23 (FGF-23), Renin (REN), Lymphotactin (XCL1), Gastric intrinsic factor (GIF), ADM, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) and Prostasin (PRSS8) (Fig 3 and Table 4, Supplementary Table 2c in S1 Data). The gene discussed is ADM; the disease is coronary artery disorder.