It would therefore be anticipated that resistance to re-infection with S. haematobium may be characterized by increased levels of ShTAL1-IgE and much lesser levels of ShTAL1-IgG4 among participants showing no signs of infection after treatment–or a balance between ShTAL1-IgE and–IgG4 indicative of a more dominant–IgE response. The gene discussed is IGHE; the disease is infection.