The results of this study indicate that Paclitaxel has a strong inhibitory effect on DLBCL and Adriamycin-resistant Pfeiffer/ADM cells, and hub genes (UBC, TSR1, WDR46, HSP90AA1, and NOP56) and ribosome biosynthesis can play a key role in Paclitaxel-induced Pfeiffer/ADM and an important potential role in the future application of Paclitaxel inhibition on Adriamycin-resistant DLBCL. This evidence concerns the gene HSP90AA1 and diffuse large B-cell lymphoma.