Consistent with the characteristic of IM HCC, all biopsied tumors in P2, P6, P7, P8, and P9 shared the clonal cluster (cluster 1, containing mutations such as CTNNB1 S45Y and ARID1A F1859fs in P2; LRP1B Q4071L in P6; and CTNNB1 S37C and CDKN2A T79fs in P8, Data Supplement). This evidence concerns the gene CDKN2A and hepatocellular carcinoma.