STUB1 and lung carcinoma: CHIP mutations originate from hematopoietic progenitor cells.43,44 Recent studies have reported 14% of patients with early-stage lung cancer and 25% of patients with late-stage solid tumors harbor CHIP mutations.45,46 Because of the difference in methodology used to detect and define CHIP variants between these studies, a comparison of results does not permit inferences about CHIP mutation frequency by cancer type and stage.