Gene expression analysis of the RNA‐seq data across the three SCLC cell lines (DMS‐53, NCI‐H82 not expressing ASCL1; and NCI‐H510A ‐not expressing NEUROD1) treated with lurbinectedin versus basal condition, made by a multi‐group comparison revealed a great level of transcriptional dysregulation, showing 2,998 genes whose expression was altered with a FDR < 0.05. The gene discussed is ASCL1; the disease is small cell lung carcinoma.