Such binding primed the arrest of elongating RNA polymerase II (RNAPII) and its subsequent degradation, having as a consequence abrogation of specific genes, such as BCL2, INSM1, MYB, MYC family members (all involved in tumorigenesis and in neuroendocrine features of the disease), ultimately triggering SCLC cell death. The gene discussed is BCL2; the disease is small cell lung carcinoma.