INSM1 and small cell lung carcinoma: Such binding primed the arrest of elongating RNA polymerase II (RNAPII) and its subsequent degradation, having as a consequence abrogation of specific genes, such as BCL2, INSM1, MYB, MYC family members (all involved in tumorigenesis and in neuroendocrine features of the disease), ultimately triggering SCLC cell death.