Here, we focused on the study of the transcriptional process underlying two of the major subtypes of SCLC, SCLC‐A and SCLC‐N, both with neuroendocrine features with which respective transcriptional dysregulation programs are carried out by ASCL1 and NEUROD1 (Rudin et al, 2019; Ireland et al, 2020). This evidence concerns the gene NEUROD1 and small cell lung carcinoma.