BNIP3 and Parkinson disease: In addition, mutations in ATP13A2, a lysosomal type 5 P‐type ATPase involved in Parkinson's disease, lead to lysosomal alterations very similar to those observed in BNIP3 KD myotubes, which include impaired lysosomal acidification, decreased lysosomal proteolytic activity, and accumulation of autophagolysosomes (Dehay et al., 2012).