CASP1 and Sepsis: 1) MALT1 might contribute to systemic inflammatory responses attributable to the infection in sepsis, which would probably lead to a significant lung injury; thus, MALT1 overexpression is correlated with unfavorable SOFA respiratory system score in sepsis patients; besides, MALT1 recruitment leads to caspase 1 activation and pyroptotic death of invariant natural killer T cells, which correspondingly lead to liver injury; thus, MALT1 overexpression is correlated with unfavorable SOFA respiratory system score and SOFA liver score in sepsis patients.15, 16, 17