Genes enriched for loss of function (LOF) mutations in MSI CRC versus MSI EC included components of the MHC class I antigen presentation pathway, including HLA‐B, B2M, NLRC5, and TAP2 (p = 0.01 to p = 2.3e‐06, Fisher's exact test) (Figure 4A). This evidence concerns the gene B2M and colorectal carcinoma.