While only two immune escape genes—JAK1 and RPL22—were more commonly subject to LOF mutations in MSI EC than MSI CRC, both were mutated at high frequency (23.8 and 31.9% cases, respectively, p = 3.0e‐04 and p = 0.02, respectively, Fisher's exact test) (Figure 4A), with the majority of JAK1 mutations being a recurrent frameshift at codon 860 (p.K860Nfs*16). The gene discussed is RPL22; the disease is colorectal carcinoma.