CD8A and cancer: Using CIBERSORT estimates of tumour immune cell fractions from the Thorsson TCGA pan‐cancer immune study [25] (in which data underwent rigorous QC and extensive batch correction), we first confirmed that MSI was associated with a substantially greater increase in intratumoural lymphocyte fraction, and CD8+ cell fraction in CRC than EC, with statistically significant interaction in both cases (PINT = 0.002 and PINT = 0.005, respectively) (Figure 3A).