Further, 61 different pathways were identified by enrichment analysis in which cancer pathways were majorly modulated via 22 genes (KEAP1, HMOX1, RBX1, MMP2, SKP1, TRAF2, RARA, VHL, APC, MDM2, ITGAV, CDH1, AXIN1, CREBBP, EP300 EPAS1, LEF1, NOS2, CTNNB1, CASP8, AR, NFE2L2) under the background of 517 proteins at the false discovery rate of 7.71E−17. This evidence concerns the gene CASP8 and cancer.