Spontaneous activation of type I IFN and proinflammatory programs observed in astrocytes, but not iPSC-NSCs or neurons, when differentiated separately is in agreement with their proposed role in AGS pathology, as they secrete IFN in the CNS (Sase et al., 2018) and proinflammatory cytokines such as CXCL10 and CCL2 upon transient silencing of AGS genes (Cuadrado et al., 2015; van Heteren et al., 2008), and mediate neurotoxicity in an in vitro iPSC-based model of TREX1 deficiency (Thomas et al., 2017). Here, CXCL10 is linked to Aicardi-Goutieres syndrome.