As shown in Figure 7, electroporating plasmids at E13.5, encoding either pNeuroD-Cre in Pum2fl/fl mice or WT TDP43 or the ALS-derived mutant TDP43A315T in WT mice, respectively, was sufficient to cell-autonomously drive a switch in expression of Sox5, Bcl11b, and Rorβ in pS. This evidence concerns the gene RORB and amyotrophic lateral sclerosis.