PUM2 and epilepsy: Reduced Pum2 function has been implicated in epilepsy in both rodents and humans (Follwaczny et al., 2017; Siemen et al., 2011; Wu et al., 2015), and altered cortical wiring in S1 during development might conceivably contribute to seizures due to perturbations of excitation/inhibition balance that propagate through the network (Guerrini and Dobyns, 2014).