CHKA and cancer: Like Chk, Etnk-1 may have a noncatalytic role in the scaffolding of protein complexes, competitive protein interactions, allosteric effects on other enzymes, subcellular targeting, and DNA binding.60 Higher expression of Etnk-1 in cancer cells may lead to the development of an ethanolamine radiotracer analogous to 11C-choline to detect cancer.61