KRAS and neoplasm: Studies have been performed on different tumor types, including brain,35,83,84 breast,85 prostate,86,87 cervix,88 and pancreas.89 HR MAS has also been applied to analyze transgenic tumor models such as a medulloblastoma that originated from a transgenic mouse overexpressing the smoothened (SMO) receptor in granule cell precursors,90 and a pancreatic tumor model with a Kras mutation.89