Additionally, mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of PD (Sarkar et al., 2017; Zhu et al., 2021), whereas the suppression of NLRP3 inflammasome‐derived proinflammatory cytokines mitigates mDAn degeneration and may be beneficial to PD patients (Ahmed et al., 2021; Gordon et al., 2018; Haque et al., 2020; Zhu et al., 2018). The gene discussed is NLRP3; the disease is Parkinson disease.