Indeed, heterologous prime-boost immunization regimens per se maybe more beneficial, i.e., ChAdOx1 nCoV-19 and mRNA-1273 or ChAdOx1 nCoV-19 and BioNTech have been shown to augment COVID-19 vaccine efficacy by enhancing spike-specific IgG, NAbs as well as CD4+ and CD8+ T cells including robust recognition of variants of concern above levels induced by homologous vaccination69–73. The gene discussed is CD4; the disease is COVID-19.