Previous studies demonstrated that there is discordance between DAS28-ESR and DAS28-CRP, with DAS28-CRP tending to yield lower values of disease activity than DAS28-ESR,36 and that discordance is greatest for women.37 Treatment response was marked for dactylitis already at 6 months in both sexes; it was also particularly notable for enthesitis in women, somewhat less in men. The gene discussed is CRP; the disease is enthesitis.