Published evidence suggests there can be anatomical and immunological differences between axial and peripheral enthesitis, and downstream disease manifestations and discrepant responses to IL-17A inhibition are observed in spondylarthritis manifestations.38 Furthermore, studies analyzing gender differences in axial spondylitis revealed that female patients have different disease manifestations due to different immunological, hormonal, and genetic responses, with an overall higher disease activity and a lower quality of life. Here, IL17A is linked to enthesitis.