NFKB1 and systemic lupus erythematosus: For example, small nuclear ribonucleoprotein particles, a hallmark autoantibody target in SLE, promote TLR7/8 driven activation of NF-κB [40] and the uptake of DNA/RNA-associated IC formed by mixing autoantibodies with cellular debris leads to the activation of dendritic cells through TLR7 [41].