NFKB1 and COVID-19: This is significant because TLR7/8 activation of NF-κB increases cytokine production [4] and, in conjunction with inflammasome activity, NF-κB drives an axis of IL-1β, IL-6, IL-12, TNFα, and Th1 T-cell hyperinflammation as part of COVID-19 immunopathology [34].