For example, it is tempting to conclude that in the context of COVID-19, induction of furin-dependent protease activity by TLR7/8 could potentially reduce viral antigen presentation [48], promote C5a prothrombotic activity [49], and enhance viral entry into cells by exposing the TMPRSS2 cleavage site on the spike protein [50]. Here, TLR7 is linked to COVID-19.