POMC and hypopituitarism: Hypopituitarism is diagnosed based on baseline blood sampling for thyroid-stimulating hormone, gonadotropin, and prolactin deficiencies, whereas for adrenocorticotropic hormone (ACTH), growth hormone, and antidiuretic hormone deficiency, dynamic stimulation tests are usually needed; repeated pituitary function assessment at regular intervals is needed for diagnosis of the predictable but slowly evolving forms of hypopituitarism [6].