In addition, further studies have shown that members of the KUP family play an important role in the high affinity K+ uptake process under K+ deficiency condition (Rubio, Guillermo & Alonso, 2010; Santa-María, Oliferuk & Moriconi, 2018). The gene discussed is ZBTB25; the disease is hyperinsulinemic hypoglycemia, familial, 4.