A preplanned subgroup analysis with CNS progression-free survival as the primary objective was conducted in patients with measurable and/or nonmeasurable CNS lesions on baseline brain scan showed that the probability of experiencing a CNS progression event was consistently lower with osimertinib versus standard EGFR-TKIs [14] This represents a major advantage as the presence of brain metastases is increased in EGFR-mutation positive NSCLC with a incidence at diagnosis of 25/30% and a 15–20% risk of CNS progression during first generation EGFR TKIs treatment [15]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.