TGM2 and metabolic dysfunction-associated steatotic liver disease: In a confirmation of our original hypothesis, we found evidence that miR-9-5p shuttled by lipotoxic hepatocytes-derived EVs could be transferred into macrophages, whereby miR-9-5p exerted inductive properties in M1 macrophage polarization to promote the progression of NAFLD through the downregulation of TGM2.