IL6 and COVID-19: However, in October 2020, Leisman et al. suggested that role of cytokine release syndrome is questionable in the etiopathogenesis of severe or critical cases of COVID-19 as mean IL-6 in these conditions were significantly lower as compared to that in other inflammatory syndromes such as Sepsis, ARDS and CAR Tcell induced cytokine release syndrome (Leisman et al. 2020).