ACAN and skeletal dysplasia: Nevertheless, it has been shown that patients with heterozygous ACAN variants displayed a milder phenotype (Gkourogianni et al., 2017; Sentchordi‐Montane et al., 2018), with brachydactyly, short stature, and milder skeletal dysplasia (Sentchordi‐Montane et al., 2018).