PTK2 and cancer: NET-associated proteases neutrophil elastase and MMP-9 can induce re-awakening of dormant cancer cells through ECM remodelling cleaving of laminin-111, leading to activation of integrin a3β1 [93] and downstream signalling molecules including FAK, ROCK, YAP and MEK, resulting in tumour recurrence, disease relapse, and metastasis [93].