As summarized in Fig. 8, FX5 ameliorated synaptic impairment through GR/BDNF/TrkB/CREB pathway, protected against neuronal apoptosis by repressing GR/PI3K/AKT/GSK3β pathway-mediated tauopathy and subsequent ER stress and repressed inflammation through GR/NF-κB/NLRP3/ASC/Caspase-1 pathway. Here, NFKB1 is linked to tauopathy.