In addition, the result that there was no difference in total arm entries of T2DM mice in all groups (Supplementary Fig. S2j and l) indicated no deficit in motor function of T2DM mice, while FX5 or AAV-si-GR treatment failed to ameliorate the total arm entries in T1DM mice (Supplementary Fig. S2i and k). Here, NR3C1 is linked to type 2 diabetes mellitus.