In the current work, we determined that small molecule 5-chloro-N-[4-chloro-3- (trifluoromethyl)phenyl] thiophene-2-sulfonamide (FX5, Fig. 1a [30]) as a non-steroidal GR antagonist improved learning and memory in both T1DM and T2DM mice. This evidence concerns the gene NR3C1 and type 2 diabetes mellitus.