From the early response of M2e-specific Trm cells to the recovery phase of infection on day 8 there was a shared increase in expression of adaptive anti-viral response genes (Nkg7, Ccl5, Ctsd, Ctsw) and lymphocyte activation and maturation-associated genes (Icos, Jak3, Id2, Ramp1, Maf, Lgals1, Lgals3) as well as genes linked to cell motility (Cxcr6, Ccr2, Itgb2, Lsp1, Glrx)(Fig. 3e, Supplementary Fig. S5b). The gene discussed is ICOS; the disease is infection.