Thus, we tested if OSA methylation patterns were associated with the genomic alterations reported in the TARGET dataset, namely ATRX, CDKN2A, MDM2, RB1, and TP53. Comparing the two primary Global profile patient subgroups (Fig. 1b), we found that RB1 alterations were enriched in the hypomethylated (good prognosis) subgroup (Fisher’s p = 0.021, OR = 3.18, 95% CI = 1.134–9.547, Supplementary Table 2). This evidence concerns the gene CDKN2A and obstructive sleep apnea syndrome.