Interestingly, targeted sequencing identified four mutations shared by all of the tissue samples, including the urothelial carcinoma: BRCA1 p.Val340GlyfsTer6, DICER1 p.Arg490His, IRS2 p.Arg744Cys, and PDGFRB p.Arg853Trp (Supplementary Table 3). This evidence concerns the gene IRS2 and urothelial carcinoma.