Examples are represented by BRCA1/2 variants in hereditary breast and ovarian carcinomas, MUTYH and NTHL1 variants in multiple colorectal polyps and cancer, and mutations in the mismatch repair (MMR) genes that predispose to Lynch syndrome, with high risk for colorectal cancer (CRC) and extra-colonic neoplasms (endometrium, ovary, ureter, stomach, and pancreas)3. This evidence concerns the gene MUTYH and colorectal carcinoma.