To determine if the lack of an intact immune system in athymic nude mice contributes to cancer-induced changes in TRPV1 expression, we measured TRPV1 expression in wildtype mice with 4NQO-induced oral SCC (oSCC, n = 4 female, 6 male) and vehicle treated mice (n = 4 female, 6 male). The gene discussed is TRPV1; the disease is cancer.