ESR1 and colonic neoplasm: PPI network analysis of common targets for RP and colon cancer showed that 14 targets had a high degree of SRC, LYN, JAK2, MAPK14, MAPK8, PTK2, PTK2B, EGFR, NFKB1, JAK1, PTPN6, SYK, FGR and ESR1.