High expression of YB1 has not only been found associated with a variety number of cancer such as laryngeal squamous cell carcinoma, non-small cell lung cancer (NSCLC), hepatocellular carcinoma, breast cancer, colorectal cancer5–10, also been reported to involve in the acquirement of chemoresistance of malignant tumors11,12. The gene discussed is YBX1; the disease is laryngeal squamous cell carcinoma.