In multivariate analysis of the features of patients with NPC, which included gender, age, histological type, LNM status, clinical stages, YB1 expression, positive expression of YB1 was identified as independent poorer prognostic factors for patients with NPC (P = 0.021), as well as lymph node metastasis, advanced clinical stages and gender (P = 0.002, P = 0.022 and P = 0.026 respectively). This evidence concerns the gene YBX1 and nasopharyngeal carcinoma.