ESR1 and breast cancer: Based on the initial gene profile screening for the CAP treated TNBC cells (MDA-MB-231 cells), three genes were selected and further analyzed in other breast cancer cell lines MCF-7 (ER+, PR+, HER2−), T-47D 7 (ER+, PR+, HER2−), SK-BR-3 (ER−, PR−, HER2+), BT-474 (ER+, PR+, HER2+), MDA-MB-231 (ER−, PR−, HER2−) and Hs574T (ER−, PR−, HER2−) (Fig. 5) were carried out.