EGFR and cancer: Johansson et al. reported that extracellular matrix and cancer-associated fibroblasts (CAFs) induced MMP–mediated cetuximab resistance in HNSCCs and suggested that several MMPs could cooperate to promote cetuximab resistance.67 This funding is consistent with our findings, which collectively support that (i) MMPs should be explored as potential cetuximab resistance biomarkers and (ii) inhibiting MMPs could improve the effects of EGFR-targeted therapies.